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41.
Penetration by a cone into snow is commonly used to characterize snow properties. However, the effects of the diameter and half-angle of the cone on the mechanical properties of snow have not been systematically studied. In addition, no estimation of material parameters in a physically-based model has been made such that the results from penetration provide only an index of snow properties. In this paper, modeling and experimental methods are used to examine the effects of cone geometry on the maximum penetration force and associated hardness, with penetrometers ranging from 2.5 to 4 mm in diameter, 15° to 45° in cone half-angle, and testing both fine-grained and coarse-grained snows. The material point method, in conjunction with the Drucker–Prager cap plasticity model, was used to obtain the theoretical penetration force-distance relationship. Global sensitivity studies were conducted that indicate that the cohesion accounts for 86% of the penetration force, followed distantly by friction angle which accounts for 27%. A general trend, for the simulation results was established: for a given half-angle, the penetration force increases with the increase of diameter which holds for most of the test data as well; for a given diameter, the penetration force decreases with the increase of half-angle, which holds for some of the test data. In addition, for a given half-angle, the hardness decreases with the increase of diameter; for a given diameter, the hardness decreases with the increase of half-angle. To take into consideration the uncertainty of test data, a simple interval-based metric was used to compare test data with simulation results; the comparison was satisfactory. The material parameters from the simulations can thus be considered as calibrated ones for the snow studied. 相似文献
42.
Intermolecular Stetter reaction of aromatic aldehydes with (E)-(2-nitrovinyl)cyclohexane catalyzed by thiazolium A has been developed. The reaction rate and efficiency are profoundly impacted by the presence of thiourea B. The reaction affords moderate to good yields of the Stetter product. Some factors influencing yield were discussed. 相似文献
43.
Theoretical investigations on the insertion reaction mechanisms of three- membered-ring silylenoid H2 Si Li F with GeH 3R(R = F, OH, NH2) have been systematically carried out by combined density functional theory(DFT) and ab initio quantum chemical calculations. The geometries of all stationary points for these reactions were optimized using the B3 LYP method and then the QCISD method was used to calculate the single-point energies. The calculated results indicate that, there are one precursor complex(Q), one transition state(TS), and one intermediate(IM) which connect the reactants and the products along the potential energy surface. The insertion reactions of three-membered-ring silylenoid with Ge H3 R proceed in a concerted manner, forming H2RSi-Ge H3 and Li F. The calculated potential energy barriers of the three reactions are 29.17, 30.90, and 54.07 k J/mol, and the reaction energies for the three reactions are –127.05, –116.91, and –103.31 k J/mol, respectively. The insertion reactions in solvents are similar to those in vacuum. Under the same situation, the insertion reactions should occur easily in the following order: GeH 3-F GeH 3-OH GeH 3-NH2. The elucidations of the mechanism of these insertion reactions provided a new mode of silicon-germanium bond formation. 相似文献
44.
45.
Specific Design of Titanium(IV) Phenolato Chelates Yields Stable and Accessible,Effective and Selective Anticancer Agents 下载免费PDF全文
Sigalit Meker Dr. Ori Braitbard Dr. Matthew D. Hall Prof. Jacob Hochman Prof. Edit Y. Tshuva 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(29):9986-9995
Octahedral titanium(IV) complexes of phenolato hexadentate ligands were developed and showed very high stability for days in water solutions. In vitro cytotoxicity studies showed that, whereas tetrakis(phenolato) systems are generally of low activity presumably due to inaccessibility, smaller bis(phenolato)bis(alkoxo) complexes feature high anticancer activity and accessibility even without formulations, also toward a cisplatin‐resistant cell line. An all‐aliphatic control complex was unstable and inactive. A leading phenolato complex also revealed: 1) high durability in fully aqueous solutions; accordingly, negligible loss of activity after preincubation for three days in medium or in serum; 2) maximal cellular accumulation and induction of apoptosis following 24–48 h of administration; 3) reduced impact on noncancerous fibroblast cells; 4) in vivo efficacy toward lymphoma cells in murine model; 5) high activity in NCI‐60 panel, with average GI50 of 4.6±2 μm . This newly developed family of TiIV complexes is thus of great potential for anticancer therapy. 相似文献
46.
Based on the Timoshenko beam model the equations of motion are obtained for large deflection of off-center impact of a column by a rigid mass via Hamilton's principle. These are a set of coupled nonlinear partial differential equations. The Newmark time integration scheme and differential quadrature method are employed to convert the equations into a set of nonlinear algebraic equations for displacement components. The equations are solved numerically and the effects of weight and velocity of the rigid mass and also off-center distance on deformation of the column are studied. 相似文献
47.
Single crystals of a new silicate carbonate, K2Ca[Si2O5](CO3), have been synthesized in a multi-components hydrothermal solution with a pH value close to neutral and a high concentration of a carbonate mineralizer. The new compound has an axial structure (s.g. P6322) with unit cell parameters a = 5.04789 (15), c = 17.8668 (6) Å. Pseudosymmetry of the structure corresponds to s.g. P63/mmc which is broken only by one oxygen position. The structure consists of two layered fragments: one of the type of the mineral kalsilite (KAlSiO4) and the other of the high-temperature soda-like α-Na2CO3, Ca substituting for Na. The electro-neutral layer K2[Si2O5] (denoted K) as well as the layer Ca(CO3) (denoted S) may separately correspond to individual structures. In K2Ca[Si2O5](CO3) the S-K layers are connected together via Ca-O interactions between Ca atoms from the carbonate layer and apical O atoms from the silicate one, and also via K-O interlayer interactions. A hypothetical acentric structure, sp.gr. P-62c, is predicted on the basis of the order-disorder theory. It presents another symmetrical option for the arrangement of K-layers relative to S-layers. The K,Ca-silicate-carbonate powder produces a moderate SHG signal that is two times larger that of the α-quartz powder standard and close to other silicates with acentric structures and low electronic polarizability. 相似文献
48.
Li Zhang Dr. Julie Jung Dr. Peng Zhang Mei Guo Dr. Lang Zhao Prof. Dr. Jinkui Tang Prof. Dr. Boris Le Guennic 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(4):1392-1398
Elaborate chemical design is of utmost importance in order to slow down the relaxation dynamics in single‐molecule magnets (SMMs) and hence improve their potential applications. Much interest was devoted to the study of distinct relaxation processes related to the different crystal fields of crystallographically independent lanthanide ions. However, the assignment of the relaxation processes to specific metal sites remains a challenging task. To address this challenge, a new asymmetric Dy2 SMM displaying a well‐separated two‐step relaxation process with the anisotropic centers in fine‐tuned local environments was elaborately designed. For the first time a one‐to‐one relationship between the metal sites and the relaxation processes was evidenced. This work sheds light on complex multiple relaxation and may direct the rational design of lanthanide SMMs with enhanced magnetic properties. 相似文献
49.
Marco Masi Maria Chiara Zonno Alessio Cimmino Pierluigi Reveglia Alexander Berestetskiy Angela Boari 《Natural product research》2018,32(13):1537-1547
Ambrosia artemisiifolia L. is responsible for serious allergies induced on humans. Different approaches for its control were proposed during the COST Action FA1203 “Sustainable management of Ambrosia artemisiifolia in Europe” (SMARTER). Fungal secondary metabolites often show potential herbicidal activity. Three phytotoxins were purified from the fungal culture filtrates of Colletotrichum gloeosporioides, isolated from infected leaves of A. artemisiifolia. They were identified by spectroscopic and chemical methods as colletochlorin A, orcinol and tyrosol (1, 2 and 3). The absolute configuration 6’R to colletochlorin A was assigned for the first time applying the advanced Mosher’s method. When assayed by leaf-puncture on A. artemisiifolia only 1 caused the appearance of large necrosis. The same symptoms were also induced by 1 on ambrosia plantlets associated with plant wilting. On Lemna minor, colletochlorin A caused a clear fronds browning, with a total reduction in chlorophyll content. 相似文献
50.